ECGC and Nano Technology to Deliver Chemo Drugs

Green-tea-based nanocarrier kills cancer cells more effectively

October 6, 2014
From: Kurzweilai.net

A drug-delivery system that may kill cancer cells more efficiently has been developed by Singapore researchers, using an antioxidant ingredient of green tea.

A key ingredient in green tea, epigallocatechin gallate (EGCG), is an antioxidant known to have therapeutic applications in the treatment of many disorders, including cancer. A*STAR’s Institute of Bioengineering and Nanotechnology (IBN) researchers have now engineered nanocarriers using EGCG that they say can deliver drugs and kill cancer cells more efficiently. Their work was published recently in Nature Nanotechnology.

“This is the first time that green tea has been used as a material to encapsulate and deliver drugs to cancer cells. Our green tea nanocarrier not only delivered protein drugs more effectively to the cancer cells; the combination of carrier and drug also dramatically reduced tumor growth compared with the drugs alone,” said Professor Jackie Y. Ying, IBN Executive Director.

A key challenge in chemotherapy is ensuring that the drugs are delivered only to the tumor to avoid harming the surrounding healthy tissues and organs. Researchers have developed drug carriers that specially target cancer cells. But these existing carriers limit the amount of drug a carrier can deliver, and are made of materials that themselves have no therapeutic effect — they may even cause side effects if used in large quantities, say the IBN researchers.

How it works

So IBN designed a therapeutic nanocarrier for drug delivery using novel compounds derived from EGCG as the core of this carrier to encapsulate drugs and proteins such as herceptin, a protein drug currently used to treat breast cancer. Here’s the recipe (referring to the diagram above):

  1. Combine herceptin (a protein drug used to treat breast cancer) with OEGCG (based on EGCG), creating a “micellar nanocomplex” that protects the protein drug from damage and removal by kidneys.
  2. Add a protective shell containing polyethylene glycol (PEG) combined with EGCG. (PEG is a “stealth” molecule that acts to camouflage the carrier, preventing it from being detected and filtered out of the body by the immune system before it reaches the tumor.)

The research team conducted animal studies to evaluate the nanocarrier, revealing that it reduced tumor growth much more effectively when compared to administering herceptin on its own: Twice as much herceptin drug accumulated in the cancer cells, suggesting improved tumor-targeting ability. Drug accumulation  was also lowered by 70% in the liver and kidney and by 40% in the lung.

IBN says it has filed a patent on the green tea nanocarrier and is developing it for clinical applications.

~~~~~~~~~~~~~~~~~~

In the meantime, drink your green tea!

Sencha, Dragonwell and Matcha provide the most ECGC.

Henry David Thoreau – If The Day and Night Are Such..

If the day and the night are such that you greet them with joy, and life emits a fragrance like flowers and sweet-scented herbs, is more elastic, more starry, more immortal — that is your success.
All nature is your congratulation, and you have cause momentarily to bless yourself.

butterfly

 The greatest gains and values are farthest from being appreciated. We easily come to doubt if they exist. We soon forget them. They are the highest reality.
Perhaps the facts most astounding and most real are never communicated by man to man.

 The true harvest of my daily life is somewhat as intangible and indescribable as the tints of morning or evening.

  It is a little star-dust caught, a segment of the rainbow which I have clutched.

Kale and Blackened-Onion Egg Puff

We planted two types of organic Kale from seeds this year, and they sure took their time to grow.  The peppery flavor of the curly Kale lends itself well to egg dishes.

I volunteer in a commercial kitchen one day a week, and last week I blackened onions for recipe and remembered how much I like that flavor… so when I got home I got busy pairing the two in this recipe inspired by an oven pancake on the Green Kitchen Stories site.

Kale, Blackened Onion Puff

Kale and Blackened-Onion Egg Puff

           Serves 6- 8

  • 1 c. chopped organic Onion
  • 5 organic Hi-Omega3 Eggs
  • 2 1/2 cups Coconut or Almond milk
  • 1 c. almond flour
  • 2 Tbs. Psyllium husk or freshly ground Flax Seeds
  • 1 Tbs. Raw Honey
  • 1 tsp. Baking powder
  • ½ tsp. Sea salt
  • ½ tsp. Black pepper
  • 2 c. finely cut organic Kale
  • 2 Tbs. chopped organic Parsley
  • 1 tsp. Black Pepper or Paprika to dust top

  • 2Tbs.organic grass-fed butter or coconut oil

Preheat the oven to 425°F

Brush saute pan with a little coconut oil. Place onions in a saute pan over medium heat. Stir until evenly blackened, but not burnt. Remove from heat and place in a small bowl.

Place a 9×11-inch baking dish in oven.

Beat eggs with whisk in a large bowl until frothy. Add milk, flour, psyllium husk, honey, baking powder, sea salt and pepper. Whisk until smooth.

Add Kale, onions and parsley, and stir well.

Remove baking dish from oven and drop in the butter. Once melted, pour the batter into the dish, sprinkle with black pepper or paprika, and return to oven.

Bake for 26-30 minutes or until lightly browned and set. Check with toothpick at 26 minutes.
Let cool slightly and serve with salad of your choice.

Kale, Blackened Onion Puff 2

~ Bon Apetit!

Would You Like Some Arsenic With That?

The following excerpt is from an article was published November 2013, by Dr. Isaac Eliaz.

It is certainly worthy of our attention, since toxins play a huge role in our overall health.

~~~~~~~~~~~

Tasteless and odorless, arsenic may appear innocuous enough; but it can be a deadly poison in your food. In sufficient quantities, the metal increases oxidation, destroys cells’ ability to create energy and ultimately causes major organ failure. To add to the danger, arsenic is a known carcinogen.toxic

Arsenic is everywhere. It’s found naturally in soil and plants. It’s used in pesticides, lumber, and infiltrates water supplies, particularly in rural communities.

For more than 60 years, farmers have fed poultry animal feed laced with arsenic because it makes the animals become fatter and grow more quickly.

The industry always argues that chickens excrete the poison and little, if any, ends up in the meat. We’re finding out this is simply not true.

High arsenic levels have also been found in rice and in rice products like brown rice syrup, rice flour, rice vinegar, rice breads and cereal. Research finds that arsenic concentrates in the rice germ that is removed to make white rice. So brown rice, which is a healthier food from the perspective of nutrient content, retains higher concentrations of arsenic.
00208
Other studies demonstrate higher levels of arsenic in rice grown in the U.S. than in Basmati or Jasmine rice from Thailand or India. Rice grown in our Southern States were found to contain the highest arsenic levels. California’s had the lowest detected levels. Consumer Reports has a handy chart listing arsenic levels in many rice brands.

Detoxify

Because arsenic is so ubiquitous in the environment, food and water, it’s unrealistic to believe we can avoid it altogether. We must actively detoxify our bodies.

The first step is to adopt a cleansing diet: Avoid processed foods, white flour and sugar products, as well as forgoing non-organic dairy, meat, eggs or poultry.

Healthy fats are crucial additions. They support healthy cell membrane function.
A detox-oriented diet generally limits animal protein to smaller portions in favor of a colorful variety of vegetables and low glycemic fruits.

Consider adding a formula incorporating modified citrus pectin (MCP) made from the white pith of citrus peels, along with modified alginates derived from brown kelp, provides a gentle, natural way to remove heavy metals.

Medicinal mushrooms support immunity and have many capabilities with regard to detoxification.  For more rounded detoxing look into a formula that contains Astragalus root, Turmeric, Fenugreek, Dandelion and Stinging nettle, or most of them.  They support organs involved in waste removal, including the liver, skin, digestive tract and lungs.

Be diligent!

Read labels and check sources of your food supply, and regularly detoxify in a gentle manner to remove those toxins that escape your diligent eye.

Sunset Tomato Salad

Our Cherry, Indigo and Heirloom Hillbilly tomatoes have been so prolific for the past month, it’s been hard to keep up.  Even after loading sacks-full for every visitor, we are left with more than we can eat.

The Hillbilly tomato can reach 2 lbs in weight!  Ours are between 14 – 18 ounces each, and super delicious.

So I’ve been making tomato sauce, tomato soup, salads and stews
 
cherry tomato vine sunset tomato vine

This salad uses two varieties of tomato, and is a simple, refreshing accompaniment to almost any main dish.

My Sunset Tomato Salad

  • 1 large Hillbilly or Pineapple Tomato (16 – 20 ozs.)
  • 14 – 16 whole Cherry Tomatoes
  • 1 small organic Red Onion, sliced in wings
    sliced sunset tomato w txt

    Hillbilly Tomatoes

  • 1 Tbs. sliced organic Mint leaves
  • 2 Tbs. organic Lemon Juice
  • 1 Tbs. Apple Cider Vinegar
  • 1 small clove organic Garlic mashed with 1/2 tsp. Sea Salt
  • 3 Tbs. ev organic Olive Oil

Cut heirloom tomato into bite size chunks.

Combine with onion, cherry tomatoes and mint in a salad bowl.

Shake salad dressing ingredient in a jar, until combined.

Dress salad and toss.  Enjoy with grilled grass-fed kabobs, free range chicken or fish.

sunset tomato salad w txt

My Sunset Tomato Salad – CUTC

 ~ In good health!

Gratitude… Each Moment’s Lining

Gratitude…

should infuse every breath you take, underline every moment you live, be the period at the end of all words you utter.

There is a way to enter into a view of life which turns on a switch, illuminating what is real from what is transitory and less real.

The following beautiful passage by Henry David Thoreau speaks perfectly to those who wish to awaken and sustain Gratitude in their lives.butterfly

I hope his words weave through your thoughts now and then, as life continues to unfold.

~~~~~~

 
If the day and the night are such that you greet them with joy, and life emits a fragrance like flowers and sweet-scented herbs, is more elastic, more starry, more immortal — that is your success. All nature is your congratulation, and you have cause momentarily to bless yourself.
 The greatest gains and values are farthest from being appreciated. We easily come to doubt if they exist. We soon forget them. They are the highest reality. Perhaps the facts most astounding and most real are never communicated by man to man.
 The true harvest of my daily life is somewhat as intangible and indescribable as the tints of morning or evening. It is a little star-dust caught, a segment of the rainbow which I have clutched.
 I learned this, at least, by my experiment: that if one advances confidently in the direction of his dreams, and endeavors to live the life which he has imagined, he will meet with a success unexpected in common hours.
He will put some things behind, will pass an invisible boundary; new, universal, and more liberal laws will begin to establish themselves around and within him; or the old laws be expanded, and interpreted in his favor in a more liberal sense, and he will live with the license of a higher order of beings.
In proportion as he simplifies his life, the laws of the universe will appear less complex, and solitude will not be solitude, nor poverty poverty, nor weakness weakness.
If you have built castles in the air, your work need not be lost; that is where they should be.
Now put the foundations under them.
~~~~ Henry David Thoreau