Published by Ralph W. Moss, Ph.D., Cancer Advisor – Sept. 30, 2015
Graviola (Annona muricata) is a well-known folk remedy for cancer, with a devoted following in some countries.

It is used as a pesticide, antimalarial, antiparasitic and antimicrobial and now as an anticancer agent (Fang 1993). But these compounds also have some general cytotoxicity, which is related to their ability to interfere with the energy use by cells (Ahammadsahib 1993).

This is what may make this herb toxic to normal cells under some conditions and has brought it to the attention of various writers, not all of whom are sympathetic to its use.

Twenty years ago, Morré and his Purdue colleague, Jerry L. McLaughlin, PhD, carried out an experiment with one particular acetogenin, bullatacin, a fatty acid compound found in some Annonaceae fruit. They showed that it almost completely inhibited ENOX2 activity in HeLa cancer cells (Morré 1995).graviola no

Scientists in Atlanta, Georgia, recently showed that whole-plant extracts of graviola leaf are indeed toxic to cancer cells. However, they caution that this extract…

“despite its superior in vitro and in vivo efficacy, resulted in death of the mice due to toxicity” (Yang 2015).

This raises the question of whether graviola is too toxic to use, and, if it is used, how great is the risk to cancer patients? A particular concern is the presence of a neurotoxin, annonacin, in the leaves.

Alexander Schauss, PhD, a well-respected scholar in the field of natural products, has spoken out forcefully against the general use of graviola in food supplements. He says that there is an association between graviola consumption and “atypical” Parkinson’s disease. He did research on this topic a dozen years ago in Guam, where the consumption of graviola is common. A 2006 report from Guadaloupe similarly made a connection between graviola and Parkinsonism.

For that reason, I would say that cancer patients should stay away from graviola, until further research shows that it is both effective at inhibiting ENOX2 in humans and that there is a safe level of consumption that will not cause or contribute to Parkinson’s disease.

Pawpaw Tree

Another question is whether a related North American plant, pawpaw (Asimina triloba) might be a safe substitute for graviola. This tree produces a surprisingly delicious tropical-tasting fruit, even in the Eastern parts of the United States.

The topic of pawpaw and cancer deserves an article of its own. But the aforementioned Dr. Jerry McLaughlin has written that pawpaw contains “promising new antitumor…agents that are found only in the plant family Annonaceae” (Alali 1998). So there is promise in pawpaw.


Ahammadsahib KI, Hollingworth RM, McGovren JP, Hui YH, McLaughlin JL. Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin. Life Sci. 1993;53(14):1113-1120.

Alali FQ, Liu XX, McLaughlin JL. Annonaceous acetogenins: recent progress. J Nat Prod. 1999;62(3):504-540. doi:10.1021/np980406d.

Lannuzel A, Höglinger GU, Champy P, Michel PP, Hirsch EC, Ruberg M. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae? J Neural Transm Suppl. 2006;(70):153-157.

Morré DJ and Morré D. ECTO-NOX PROTEINS: GROWTH, CANCER AND AGING. New York: Springer, 2013. (List price of $267 but available from the Harvey H. and Donna M. Morré Foundation for Cancer Research, 1112 Cherry Lane, West Lafayette, IN 47906 by enclosing a check for a donation of $100 made out to the Foundation and also by providing a mailing address.)

Yang C, Gundala SR, Mukkavilli R, Vangala S, Reid MD, Aneja R. Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer. Carcinogenesis. 2015;36(6):656-665. doi:10.1093/carcin/bgv046.


D. James Morré, PhD
Dorothy Morré, Ph

Green tea is not the only thing that can inhibit ENOX2. There are several well-known anticancer agents that do so, including two jack-of-all-trade drugs, cisplatin and doxorubicin (better known by its trade name, Adriamycin®). Almost as powerful, and far less toxic, is a specific combination of concentrated green tea and pure chili pepper, which is sold as “Capsol-T.”

It combines these two ingredients in a particular ratio, which is determined experimentally for each product lot. This has the effect of blocking the dangerous ENOX2, which functions on the surface of cancer cells.

 “A major factor in the effectiveness of Capsol-T is the necessity to take the product every four hours even during the night. The effect of Capsol-T on ENOX2 is one of reversible inhibition….The effect of both green tea and Capsol-T is transient and goes away in a matter of a few hours. If cancer cells can be prevented from growing for more than three or four days they are likely to undergo programmed cell death.”

 There are currently ~6,000 scientific publications indexed in PubMed on the topic of green tea. Over ~2,000 of these contain references to the main medicinal substance found in tea, the polyphenol (or catechin) dubbed epigallocatechin gallate or EG

Cg. There are 1,300 articles referencing both EGCg and cancer.

 Large Amount of Research

Complementary and alternative medicine (CAM) subjects are usually deficient in solid research and, often, scientific research lags behind popular interest. But you can see that green tea is among the best researched subjects in the nutritional universe.

Unfortunately, the clinical investigation of green tea in human cancer patients has lagged behind the easier-to-perform laboratory studies. However, in the April 2015 issue of the journal Prostate,there was a very interesting article on the effects of brewed green tea compared to brewed black tea (and plain water) on various blood markers associated with prostate cancer development and progression.

Dr. Suzanne M. Henning and colleagues at the David Geffen School of Medicine, University of California, Los Angeles, CA (UCLA) conducted the study. In this phase II trial, 113 men who had been diagnosed with prostate cancer were randomized to consume six cups daily of brewed green tea, brewed black tea or water prior to undergoing a radical prostatectomy (RP) operation. The authors looked at a variety of markers of progression. Patients who consumed green tea (but not either black tea or water) had a significant decrease in the amount of nuclear factor kappa B [NFκB]. NFκB is a very important marker that is often associated with more aggressive cancers.

In fact, tea polyphenols (including EGCg) were detected in the prostate tissue of 32 of the 34 men who received green tea, but not in the two other groups. Evidence of a systemic antioxidant effect was  observed only with green tea consumption. Also, only green tea led to a statistically significant decrease in serum prostate-specific antigen (PSA) levels.

The authors concluded “future longer-term studies are warranted to further examine the role of GT [green tea, ed.] for prostate cancer prevention and treatment, and possibly for other prostate conditions such as prostatitis.”

In September, this conclusion was seconded by a well known urologist at New York University’s Langone Medical Center, New York, Samir S. Taneja, MD. Writing in the Journal of Urology(official journal of the American Urological Association), Taneja wrote:

 “The authors of this [UCLA, ed.] study provide a well executed trial with defined, measurable end points. While the study does not tell us if green tea will prevent prostate cancer or slow its growth, it offers insight into potential mechanisms and validates a biological effect of the agents, such that future clinical trials of efficacy appear warranted” (Taneja 2015).

Such a trial will probably be less significant if the green tea in question is given solely as a brewed drink than in the form proposed by the Morrés, namely as Capsol-T. The reason for this has to do with the presence of ENOX2 at the surface of most cancer cells (including prostate cancer cells) and the ability of various substances, including green tea catechins, to inhibit in turn the functions of ENOX2.

 It is important to note that Capsol-T must be taken according to a rigorous schedule.

Dr. Morré recently told me:

“A major factor in the effectiveness of Capsol-T is the necessity to take the product every four hours even during the night. The effect of Capsol-T on ENOX2 is one of reversible inhibition….The effect of both green tea and Capsol-T is transient and goes away in a matter of a few hours. If cancer cells can be prevented from growing for more than three or four days they are likely to undergo programmed cell death.

However, if the Capsol-T or green tea levels are intermittent, the cancer cells will resume growth when the levels reach a low blood level and the clock starts over again and will never be killed and through a ‘survival of the fittest’ selection process may even become resistant. This is why, to be effective, Capsol-T must be taken every 4 hours, even during the night” (personal communication, September 21, 2015).

For a better understanding, interested readers can and should read the Morrés’ articles (e.g., Hanau 2014) and, especially, their groundbreaking book, ECTO-NOX Proteins: Growth, Cancer, and Aging (Springer 2013).


Hanau C, Morré DJ, Morré DM. Cancer prevention trial of a synergistic mixture of green tea concentrate plus Capsicum (CAPSOL-T) in a random population of subjects ages 40-84. Clin Proteomics. 2014;11(1):2. doi:10.1186/1559-0275-11-2.

Henning SM, Wang P, Said JW, et al. Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy. Prostate. 2015;75(5):550-559. doi:10.1002/pros.22943.

Mangal M, Khan MI, Agarwal SM. Acetogenins as potential anticancer agents. Anticancer Agents Med Chem. June 2015.

Morré DJ, de Cabo R, Farley C, Oberlies NH, McLaughlin JL. Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes. Life Sci. 1995;56(5):343-348.

Taneja SS. Re: Randomized Clinical Trial of Brewed Green and Black Tea in Men with Prostate Cancer Prior to Prostatectomy. J Urol. 2015;194(3):704-705. doi:10.1016/j.juro.2015.06.050.

Yang C, Gundala SR, Mukkavilli R, Vangala S, Reid MD, Aneja R. Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer. Carcinogenesis. 2015;36(6):656-665. doi:10.1093/carcin/bgv046.


Detox Your Organs with These Targeted Foods

A handy chart to print and keep in your kitchen.. courtesy of Econugenics.




A Powerful Golden Detox Tea

Golden Detox Spice Tea

Along with its anti-inflammatory and anti-coagulant properties, Turmeric is a metabolism boosting spice.  It is a great detox agent, helping the liver break down toxic chemicals.

This delicious spice tea is a wonderful drink on its own.  You can double the recipe and sip throughout the day.

  • 2 cup Hot Water cay-1326363
  • 1/2 tsp Turmeric
  • 1/2 tsp Powdered Ginger
  • 1 small Ceylon Cinnamon stick
  • 1/2 tsp. Coconut Oil (aids in absorbing turmeric)
  • 1 tsp raw Honey
  • Pinch of Cayenne
  • Pinch freshly cracked Black Pepper (boosts effectiveness of turmeric)
  • Juice of 1/2 small organic Lemon


Bring 2 cups of water to a boil.  Add ingredients except lemon and honey. Simmer for 5 min.  Remove cinnamon stick. Add lemon and honey.

Let cool slightly and enjoy.

~ Cheers! 

Can 12 Minute Workouts Rival Cardio?

Even when you don’t have a lot of time… You can squeeze in 10 minute workouts.

There is a growing understanding in the fitness world that working out longer won’t necessarily get you better results.

And yet, many people still diligently put in an hour or more on the treadmill or elliptical machine three or more times a week.

But not only does regular, steady-state cardio take way longer to actually do, it’s also way less efficient overall than12-minute-athlete-push-ups-850x400 high intensity interval training (HIIT).
In fact, if you gave up all regular cardio and replaced it with HIIT-style training, you’d not only have way more time in your day, you’ll also be in better shape.

Here are 5 reasons to ditch your regular cardio for HIIT today:

1. It’s more efficient.

2. It’s way less boring.

3. You can do it anywhere.

4. You’ll get in better shape in less time.

5. It’ll get you strong.


Youtube has a large number of 10 minute workouts targeting different muscle groups.  They’re easy to do before you shower in the morning, and actually fun.

Check out the Popsugarfit videos.

Treat Diabetes and Expel Toxins with This Crunchy Vegetable

Cucumbers belong to the same plant family as squash, pumpkin, and watermelon.  They are 90% water like watermelon, so will keep you hydrated on a hot summer day.  Cucumber packs K, B vitamins, copper, potassium, vitamin C, and manganese, so they can help you to avoid the nutrient deficiencies that are widespread in our diet.

Cucumbers contain multiple B vitamins, including vitamins which are known to help ease feelings of anxiety and stress.  Placing a cucumber slice on the roof of your mouth may help rid your mouth of odor-causing bacteria.

You can enjoy cucumbers in many ways… fermented or raw in vinegar-based salads, as a dipping chip with beans or salsa, cut into spears and soaked in a bit of lemon and a sprinkle of sea salt, or, if you’re looking for something different, as a refreshing base for your vegetable juicing.


cuke benefits

Mammograms Do Not Improve Survival Stats

Mammograms have No Impact on Mortality according to latest study, confirming other such findings.

By Dr. Mercola

Do annual mammograms save lives?file0001039144177

Several studies over the past few years have concluded that mammograms do not save lives, and may actually harm more women than they help, courtesy of false positives, over-treatment, and radiation-induced cancers.

According to research1 published in 2010, the reduction in mortality as a result of mammographic screening was so small as to be nonexistent — a mere 2.4 deaths per 100,000 person-years were spared.

Another study2 published in The Lancet Oncology in 2011 demonstrated, for the first time, that women who received the most breast screenings had a higher cumulative incidence of invasive breast cancer over the following six years than the control group who received far less screenings.

Now, researchers from Harvard and Dartmouth have published a paper3 in which they present similar conclusions.

Mammograms Have No Impact on Breast Cancer Mortality

After analyzing cancer registry data from 16 million women in 547 counties across the United States, they found “no evident correlation between the extent of screening and 10-year breast cancer mortality.”

The researchers concluded that mammograms primarily find small, typically harmless, or non-lethal tumors, leading to widespread overdiagnosis.

As explained by Dr. Otis Webb Brawley, chief medical officer of the American Cancer Society and author of the book, How We Do Harm, the term “overdiagnosis” in cancer medicine refers to:

“…a tumor that fulfills all laboratory criteria to be called cancer but, if left alone, would never cause harm. This is a tumor that will not continue to grow, spread, and kill. It is a tumor that can be cured with treatment but does not need to be treated and/or cured.”

Also, echoing results found in 2011, higher screening rates were associated with higher incidence of breast cancer. As reported by The LA Times:4

“For every 10-percentage-point increase in screening rates, the incidence of breast cancer rose by 16 percent… That worked out to an extra 35 to 49 breast cancer cases for every 100,000 women…

The researchers also examined breast cancers according to their stage at diagnosis, a marker of a tumor’s aggressiveness. More screening was associated with a higher incidence of early-stage breast cancers but no change for later-stage tumors, according to the study.

How can this be?

‘The simplest explanation is widespread overdiagnosis, which increases the incidence of small cancers without changing mortality,’ the study authors wrote. ‘Even where there are 1.8 times as many cancers being diagnosed, mortality is the same.’”


To Screen or Not to Screen?

Clearly, the issue of breast cancer screening using mammography can be a deeply emotional one. Virtually all discussions relating to cancer are. A recent article in Forbes Magazine5 paints a vivid picture of most women’s fears, and warns of the dangers of not getting diagnosed in time.

While it needs to be an individual choice, I believe it can be valuable to take a step back and look at the big picture, which includes population-based statistics such as those presented above.

It’s also well worth investigating all available options and, of course, weigh the risks and benefits associated with each. As reported by Care2:6

“[The] study authors… point to a balance of benefits and harms and believe mammography is likely most favorable when directed at women who are at high risk — not too rarely and not too frequently.

They also believe watchful waiting, rather than immediate active treatment, is probably a good option in some cases.”

A main objection to mammography is the fact that it uses ionizing radiation to take images of your breasts, and it’s a well-established fact that ionizing radiation can cause cancer.

So the idea that the “best” way for you to avoid dying from cancer is to expose yourself to cancer-promoting radiation at regular intervals for decades on end (in order to catch the cancer early) really falls short on logic — especially since there are non-ionizing radiation imaging techniques available.

Results published in the British Medical Journal7 (BMJ) in 2012 show that women carrying a specific gene mutation called BRCA1/2 are particularlyvulnerable to radiation-induced cancer.

Women carrying this mutation who were exposed to diagnostic radiation before the age of 30 were twice as likely to develop breast cancer, compared to those who did not have the mutated gene.

They also found that the radiation-induced cancer was dose-responsive, meaning the greater the dose, the higher the risk of cancer developing. The authors concluded that:

“The results of this study support the use of non-ionizing radiation imaging techniques (such as magnetic resonance imaging) as the main tool for surveillance in young women with BRCA1/2 mutations.”


Mammograms Do Not Reduce Mortality Beyond That of Physical Examination

Last year, one of the largest and longest investigations into mammography was published.8

It involved 90,000 women who were followed for 25 years, and it sent shockwaves through the medical industry when it reported that the death rates from breast cancer were virtually identical among women who got annual mammograms and those who did not.

Moreover, it found that mammography screening had harmful effects. As reported by The New York Times:9

One in five cancers found with mammography and treated was not a threat to the woman’s health and did not need treatment such as chemotherapy, surgery, or radiation.”

At the outset of the study, the women, aged 40-59, were randomly assigned to receive either five annual mammography screens, or an annual physical breast examination without mammography.Over the course of the study, 3,250 of the women who received mammography were diagnosed with breast cancer, compared to 3,133 in the non-mammography group.

Of those, 500 women in the mammography group, and 505 in the control group, died from the disease. However, after 15 years of follow-up, the mammography group had another 106 extra cancer diagnoses, which were attributed to overdiagnosis. According to the authors:10

“Annual mammography in women aged 40-59 does not reduce mortality from breast cancer beyond that of physical examination or usual care when adjuvant therapy for breast cancer is freely available. Overall, 22 percent of screen detected invasive breast cancers were over-diagnosed, representing one over-diagnosed breast cancer for every 424 women who received mammography screening in the trial.”

The rate of overdiagnosis (22 percent) is virtually identical to that found in a 2012 Norwegian study,11 which found that as many as 25 percent of women are consistently overdiagnosed with breast cancer that, if left alone, would cause no harm. Other studies that have come to similar conclusions include the following:

  • In 2007, the Archives of Internal Medicine12 published a meta-analysis of 117 randomized, controlled mammogram trials. Among its findings: rates of false-positive results are high (20-56 percent after 10 mammograms)
  • A 2009 meta analysis by the Cochrane Database review13 found that breast cancer screening led to a 30 percent rate of overdiagnosis and overtreatment, which increasedthe absolute risk of developing cancer by 0.5 percent.  The review concluded that for every 2,000 women invited for screening throughout a 10 year period, the life of just ONE woman was prolonged, while 10 healthy women were underwent unnecessary treatment.

Know the Signs and Symptoms of Breast Cancer

Mammograms can also miss the presence of cancer. According to the National Cancer Institute (NCI), mammograms miss up to 20 percent of breast cancers present at the time of screening. Your risk for a false negative is particularly great if you have dense breast tissue, and an estimated 49 percent of women do.14 Mammography’s sensitivity for dense breasts is as low as 27 percent,15 which means that about 75 percent of dense-breasted women are adeoderant fyit risk for a cancer being missed if they rely solely on mammography. Even with digital mammography, the sensitivity is still less than 60 percent.

Considering the mortality rate from breast cancer is virtually identical whether you get an annual mammogram or an annual physical breast exam, it suggests physical examination can go a long way toward detecting a potential cancer. It certainly makes sense to familiarize yourself with your breasts and the signs and symptoms of breast cancer.16,17 If you notice any of the following symptoms, be sure to address it with your doctor, even if you’re not due for an annual checkup yet.

Lump in the breast (keep in mind that breast lumps are common, and most are not cancerous) Dimpling of the breast surface, and/or “orange peel” skin texture
Pain or unusual tenderness or swelling in the breast Visible veins on the breast
Retracted nipple Change in size or shape of the breast
Nipple discharge Enlarged lymph nodes (located in the armpit)
Vaginal pain Unintentional weight loss
  • Curcumin is the active ingredient in turmeric and in high concentrations can be very useful in the treatment of breast cancer. It shows immense therapeutic potential in preventing breast cancer metastasis.
  • There is intriguing data suggesting metal underwire bras increase your breast cancer risk.
  • Omega-3 deficiency is a common underlying factor for cancer, eat wild-caught, cold water fish 3x a week, or take a mercury-free supplement
  • Charcoal or flame broiled meat is linked with increased breast cancer risk. Acrylamide — a carcinogen created when starchy foods are baked, roasted, or fried — has been found to increase breast cancer risk as well.
  • Optimizing your gut flora will reduce inflammation and strengthen your immune response. Adding naturally fermented food to your daily diet is an easy way to prevent cancer or speed recovery. Or add a high-quality probiotic supplement as well, but naturally fermented foods are the best.
  • Vitamin A may also play a role in helping prevent breast cancer.19 It’s best to obtain it from vitamin A-rich foods, rather than a supplement. Your best sources are organic egg yolks, raw butter

One of the BEST DEFENSES against the risk of CANCER

Optimizing your vitamin D level alone has been shown to reduce your chances of breast cancer by at least 50 percent and double your chances of surviving breast cancer should you receive a breast cancer diagnosis.  Aim for a reading of 50 – 65ng/ml.