In the News: Integrative Medicine: Antioxidants and Chemotherapy

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Antioxidants and Chemotherapy

By Drs. Kay judge and Maxine Barish-Wreden

Published: Thursday, May. 31, 2012

Inflammation, and the use of antioxidants to put out inflammatory fires, is a hot topic these days. What do we mean by inflammation?

Inflammation is a natural and necessary response in the body whenever we are accosted by harmful germs or when we injure ourselves. When this occurs, our immune system steps in to fight foreign invaders and to bring our body back into balance so that we can heal.

Inflammatory chemicals are produced during this process, which can be harmful to our tissues, but antioxidants in our foods, such as vitamins C and E, help to quell this response and restore order to our tissues.

Inflammation can run amok, however, and cause persistent damage to healthy tissue, especially if we smoke or if we are overweight or obese. Chemotherapy drugs that are used to treat cancer also produce severe inflammation in the body, and this particular inflammatory response helps to kill off cancer cells. But it also harms healthy tissue in the process.

Many oncologists have been fearful of having their patients take any antioxidants during chemotherapy for fear that antioxidants might reduce the effectiveness of the chemo.

In a recent article in the journal Alternative and Complementary Therapies, Dr. Keith Block, a renowned integrative cancer specialist affiliated with the University of Illinois, discussed his review of more than 2,300 studies on the use of antioxidants during chemotherapy, and his report is very reassuring.

In summary, antioxidants often help to reduce side effects from chemotherapy, and this may allow patients to complete their full course of medication without interruption, which itself leads to better outcomes. Certain antioxidants also enhance the effectiveness of chemotherapy, reduce long-term toxicity and improve survival.

Not a single study reviewed by Block showed any evidence of antioxidants interfering with the effectiveness of chemotherapy. In fact, a recent article looking at the impact of antioxidants in Chinese women undergoing treatment for invasive breast cancer found that use of antioxidant vitamin supplements in the first six months after diagnosis resulted in a reduced risk of both mortality and cancer recurrence.

Other studies have suggested survival benefit in certain cancers when patients take melatonin, as well as reduced toxicity from chemo with the use of glutathione and coenzyme Q10 among others.

So, if you are affected by cancer, what should you be thinking about to protect yourself during and after chemotherapy? First and foremost, begin by eating a super-healthful, plant-based diet that is loaded with dark-colored fruits and veggies so that you maximize your intake of antioxidants from your food, which is the most powerful way to get them.

You can also consider supplementing your diet with some of the more powerful antioxidants, such as fish oil, coenzyme Q10, vitamin C, vitamin E and selenium, though we recommend that you meet with an integrative cancer specialist first so that you can determine which supplements are ideal for you, given your particular tumor as well as your treatment regimen.

And for those of you who have been affected by cancer, either because you or a loved one have faced this disease, there is a conference coming to Sacramento in September that you should know about. It's titled "Cancer as a Turning Point, From Surviving to Thriving," and it is a gathering of some of the best and most inspiring experts in this business.

Cancer as a Turning Point is sponsored by the non-profit organization Healing Journeys, whose vision is that everyone touched by cancer or any life-altering condition be empowered to move from surviving to thriving. This conference is usually offered in two cities across the country every year.  The conference is free to all attendees, though donations are greatly appreciated to offset the cost, and donations are also tax-deductible. For more information, and to register, go to www.healingjourneys.org.

And for more information on an integrative approach to cancer treatment, look at Block's 2009 book "Life Over Cancer" (Bantam, $28, 608 pages) or Alschuler's gem that she co-wrote with Karolyn Gazella, "The Definitive Guide to Cancer: An Integrative Approach to Prevention, Treatment, and Healing" (Celestial Arts, $25, 496 pages), now in its third edition.

~ Be Well! ♥

Exercise and the Development of Cancer

Move, move, move...

Researchers have known for years that people who are active and trim are less likely to develop cancer. And survivors who exercise and keep a healthy weight are less likely to relapse.

Only recently, however, have scientists begun to untangle how staying active helps keep cancer at bay.

While exercise may not change the inner workings of a tumor cell, physical activity may change the cell's neighborhood — the surrounding tissue, blood vessels and immune cells — known as the "microenvironment," says Patricia Ganz, a breast cancer specialist at UCLA's Jonsson Comprehensive Cancer Center.

"It's a new frontier for cancer research," says Pamela Goodwin, professor of medicine at Mount Sinai Hospital, University of Toronto.

Healthy neighborhoods are as important to cells as they are to children, says William Li, president of the Boston-based Angiogenesis Foundation, which funds research in cancer and other diseases.

He compares a lone tumor cell to a "bad kid" living in a good neighborhood. Even an aspiring juvenile delinquent won't be able to cause much trouble if he's surrounded by watchful parents, neighbors and local police. Exercise helps improve the neighborhood, keeping cancers in check, Li says. Failing to exercise — and putting on a lot of weight — damages the neighborhood, making it easier for cancers to wreak havoc.

In particular, exercise helps to prevent chronic inflammation, a process that can fuel cancers by changing the neighborhood around a tumor cell. Exercise helps lower levels of both insulin and sex hormones, such as estrogen, which release growth factors that let tumor cells survive and spread, Li says. And, as Doria has learned, exercise also helps relieve psychological stress, which may further reduce inflammation, Ganz says."

Read full article here.

~ Be Well! ♥

AHCC - ImmPower

ImmPower : Produced by American Biosciences of Blauvelt, NY  

A fermented extract produced from the mycelium of hybridized medicinal mushrooms grown in the extract of rice bran, AHCC been shown to significantly improve the immune system by increasing the production of the body’s “killer cells”, whose function is to destroy abnormal cells and invading organisms in the body.

Currently used in over 700 clinics throughout Asia, AHCC has gained wide acceptance due to the volume of research devoted to its applications. As the subject of over 100 research papers from the world’s leading research centers, AHCC has been studied at prestigious U.S. institutions such as the UC Davis Cancer Center, Columbia Presbyterian Medical Center, the Yale School of Medicine and the Harvard-affiliated Brigham and Women’s Hospital, among others.

The most important factor driving the acceptance of AHCC at cancer clinics has been its impact on reducing the side effects of chemotherapy. AHCC has been shown to help reverse the suppression of immunity (that results from cytotoxic chemotherapy treatments) by significantly raising patients’ white blood cell counts, as well as contribute to the prevention of chemically induced alopecia (hair loss), the reduction of nausea and vomiting and the protection of the bone marrow (by helping prevent myelo-supression and anemia, which contribute to the patient’s fatigue). Read full article here.

Research shows provides unsurpassed support for the immune system's front-line defenses:*

• Maintaining peak Natural Killer cell function*
• Supporting enhanced cytokine production*
• Promoting optimal T-cell and macrophage activity*

"Animal studies suggest that AHCC has antioxidant effects and may protect against disorders induced by oxidative stress and also enhance resistance against bacterial and viral infections.

A study of healthy subjects aged 50 years and older suggests that AHCC improves T-cell immune responses via increased production of interferon-l and tumor necrosis factor-alpha for up to 30 days after treatment. In healthy humans, AHCC increased dendritic cell number and function."

Herb-Drug Interactions:  AHCC can induce CYP450 2D6. This may decrease the activity of other drugs, like doxorubicin or ondansetron, which are substrates of this enzyme.  Read full article here.