A High-Fat Diet Helps Starve Cancer

The following is courtesy of Dr. Mercola

In 1931, Dr. Otto Warburg won the Nobel Prize  Physiology or Medicine for his discovery that cancer cells have a fundamentally different energy metabolism compared to healthy cells.

Most experts consider him to be the greatest biochemist of the 20th century. His lab staff also included Hans Krebs, Ph. D., after whom the Krebs cycle1 was named.

The Krebs cycle refers to the oxidative reduction pathways that occur in the mitochondria. So just how does the metabolic inflexibility of cancer cells differ from healthy cells?

A cell can produce energy in two ways: aerobically, in the mitochondria, or anaerobically, in the cytoplasm, the latter of which generates lactic acid — a toxic byproduct. Warburg discovered that in the presence of oxygen, cancer cells overproduce lactic acid. This is known as The Warburg Effect.

Warburg concluded that the prime cause of cancer was the reversion of energy production from aerobic energy generation to a more primitive form of energy production, anaerobic fermentation.

To reverse cancer, he believed you had to disrupt the energy production cycle that is feeding the tumor, and that by reverting back to aerobic energy metabolism you could effectively “starve” it into remission.

Sugar Feeds Cancerfile000473112264

Warburg’s discovery is that cancer cells are primarily fueled by the burning of sugar anaerobically. Without sugar, most cancer cells simply lack the metabolic flexibility to survive. As noted in the New York Times (NYT) featured article:

“[T]he Warburg effect is estimated to occur in up to 80 percent of cancers. [A] positron emission tomography (PET) scan, which has emerged as an important tool in the staging and diagnosis of cancer works simply by revealing the places in the body where cells are consuming extra glucose.

In many cases, the more glucose a tumor consumes, the worse a patient’s prognosis.”


The Warburg Revival

In recent years, scientists have come to realize that it’s not the genetic defects that cause cancer. Rather mitochondrial damage happens first, which then triggers nuclear genetic mutations. As noted by The New York Times:

“There are typically many mutations in a single cancer. But there are a limited number of ways that the body can produce energy and support rapid growth. Cancer cells rely on these fuels in a way that healthy cells don’t.

The hope of scientists at the forefront of the Warburg revival is that they will be able to slow — or even stop — tumors by disrupting one or more of the many chemical reactions a cell uses to proliferate, and, in the process, starve cancer cells of the nutrients they desperately need to grow.

Even James Watson, Ph.D. one of the fathers of molecular biology, is convinced that targeting metabolism is a more promising avenue in current cancer research than gene-centered approaches …

Cancer-Causing Genes Regulate Cells’ Nutrient Consumption

Scientists have discovered that a number of genes known to promote cancer by influencing cell division — including a gene called AKT — also regulate cells’ consumption of nutrients. So certain genes do appear to play a role in cancer cells’ overconsumption of sugar.

“Dr. Craig Thompson, the president and chief executive of the Memorial Sloan Kettering Cancer Center, has been among the most outspoken proponents of this renewed focus on metabolism …

His research showed that cells need to receive instructions from other cells to eat, just as they require instructions from other cells to divide.

Thompson hypothesized that if he could identify the mutations that lead a cell to eat more glucose than it should, it would go a long way toward explaining how the Warburg effect and cancer begin,” The New York Times writes.

The protein created by AKT is part of a chain of signaling proteins that is mutated in up to 80 percent of all cancers. Thompson says that once these proteins go into overdrive, a cell no longer worries about signals from other cells to eat; it instead stuffs itself with glucose.

Thompson discovered he could induce the ‘full Warburg effect’ simply by placing an activated AKT protein into a normal cell. When that happens, Thompson says, the cells begin to do what every single-celled organism will do in the presence of food: eat as much as it can and make as many copies of itself as possible.”

Whereas healthy cells have a feedback mechanism that makes it conserve resources when there’s a lack of food, cancer cells do not have this mechanism, and feed continuously.

As noted by Dr. Chi Van Dang, director of the Abramson Cancer Center at the University of Pennsylvania, cancer cells are “addicted to nutrients,” and “when they can’t consume enough, they begin to die.”

Novel Treatment Offers Hope for Cancer Patients

A brilliant Korean biochemist by the name of  Young Hee Ko, Ph.D., who was working in the early 2000s with Peter Pedersen, a professor of biological chemistry and oncology at Johns Hopkins, made a remarkable discovery that offers a great deal of hope for cancer patients. Today Ko is the CEO of KODiscovery at the University of Maryland BioPark.

What the two of them noticed was that when cancer cells overproduce lactic acid, they have to produce more pores to let lactic acid out, or else the cancer cell will die from the inside out. As mentioned, lactic acid is a very toxic substance. Pondering how to best exploit this functional difference, Ko remembered a compound called 3-bromopyruvate (3BP), which she’d worked with while getting her Ph.D.

This molecule looks very similar to lactic acid, but it’s highly reactive. She thought 3BP might be able to slip into the pore that’s allowing the lactic acid to be expelled from the cancer cell, thereby preventing the lactic acid from spilling out. Her hunch was correct. In over 100 lab tests, 3BP blew away all of the chemotherapy drugs she used for comparison. In a nutshell, 3BP “melts” tumors away by preventing the lactic acid from leaking out of the cancer cell, thereby killing it from the inside.

Old Diabetes Drug May Find New Use in War on Cancer..IMG_9639

The Importance of Diet for Successful Cancer Treatment..

Continue reading here . . Full Article

  ~ In Good Health! 

Is Folic Acid Helpful or Harmful?

FolicFolic acid may be problematic with people who are concerned about Cancer, because of its ability to affect methylation.  There has also been some negative research associated with the acid form.
For Cancer patients it may be wise to avoid folate in amounts higher than one would find in a multi-vitamin.  Dietary sources are not a problem –leafy greens being the best source.
Reviewing the literature on cancer and vitamin B12 (and folic acid), we see both positive and negative studies. Some research suggests these nutrients may help fight cancer, whereas a handful of studies show the opposite, with potential to foster tumor growth or progression.
One reason for the divergent findings may be that these B vitamins play a role in controlling gene expression. B vitamins are involved in “methylation,” a chemical process which is used to regulate the expression of genes. When a gene is methylated, it is silenced.
Conversely, a lack of methylation (associated with low levels of B12 and folic acid) can lead to up-regulation of gene expression.
A concern with supplementation of high dose vitamin B12 or folic acid is that we do not have control over which genes may be influenced. And there is a risk that helpful tumor suppressor genes could be silenced or oncogenes (genes that foster tumor growth) might potentially be up-regulated.
Until further research clarifies who might benefit vs who is at risk, our best suggestion at this time is to avoid high dose supplementation with vitamin B12 or folic acid (in amounts higher than found in a multiple vitamin)….UNLESS there is evidence of functional deficiency of these nutrients.


  1. Elevated Plasma Vitamin B12 Levels as a Marker for Cancer
  2. Folic Acid Supplementation and Cancer Risk
  3. Folate and cancer prevention: a closer look at a complex picture
Note: Consult with your Naturopathic Doctor before adding any supplement to you regimen.

Low Level of Melatonin Raises Cancer Risk and Speeds Aging

For the past 5 years, Melatonin has been part of my bedtime regimen.  I slowly went from 1 mg to 16 mg during treatment, and am now on a maintenance dose of 3 – 4 mg every night.file2181243304653

Within a few months of starting Melatonin, I noticed better energy and resilience, and the skin on my face and neck looked smoother.
I am sensitive to light, so I sleep in a very dark room, not even a light from an alarm clock or extension cord button.
I use blackout curtains on all windows.  As mentioned in the study, even the faintest light can disrupt our Circadian cycle and deplete Melatonin levels.

A LifeExtension Clinical Study highlights the critical role of Melatonin in many areas of health, most importantly Cancer Prevention and Management.

Below is an excerpt, for the full article CLICK HERE.

Melatonin’s Anti-Cancer Mechanisms

Melatonin can kill directly many different types of human tumor cells. It is a naturally produced cytotoxin, which can induce tumor cell death (apoptosis). In instances where the tumor has already established itself in the body, melatonin has been shown to inhibit the tumor’s growth rate.

Night Light, Melatonin, Meditation, and Cancer Incidence

Low levels of melatonin have been associated with breast cancer occurrence and development.
Women who work predominantly at night and are exposed to light, which inhibits melatonin production and alters the circadian rhythm, have an increased risk of breast cancer development.

In contrast, higher melatonin levels have been found in blind and visually impaired people, along with correspondingly lower incidences of cancer compared to those with normal vision, thus suggesting a role for melatonin in the reduction of cancer incidence.file0002026188522

Light at night, regardless of duration or intensity, inhibits melatonin secretion and phase-shifts the circadian clock, possibly altering the cell growth rate that is regulated by the circadian rhythm. Disruption of circadian rhythm is commonly observed among cancer patients and contributes to cancer development and tumor progression.

Cancer alters neuroendocrine system function in such a way that melatonin levels are lower in patients with non-small-cell lung cancer. Indeed, the circadian rhythm of melatonin is also altered in advanced gastrointestinal malignancies, such as colorectal, gastric, and pancreatic cancer, with respect to healthy humans.

Deregulation of many circadian clock functions in the human body— including blood pressure, temperature, hormones, sleep-wake pattern, immune function, and digestive activity—has been used as an independent prognostic factor of survival time and tumor response for patients with certain metastatic cancers.

The circadian rhythm alone is a statistically significant predictor of survival time for breast cancer patients.110 Several studies have shown that the circadian clock is involved in tumor suppression at the systemic, cellular, and molecular levels, and that cancer should no longer be treated as a local disorder. For instance, the circadian clock regulates the immune response.

Disruption of cirbraincadian rhythms could therefore lead to immunosuppression, which could disrupt cancer cell immunosurveillance and promote tumor development; however, melatonin as a circadian mediator can target the endogenous clock, and has been shown to inhibit immunosuppression.


Melatonin Dosage for Cancer Patients

While the optimal dose of melatonin for treating different types of cancer has not yet been established, the many clinical studies by Lissoni and colleagues have shown that doses of 10-50 mg of melatonin nightly are beneficial to cancer patients. Those recently diagnosed with slow-growing or early-stage cancer may wish to consider supplementing with 3 to 6 mg melatonin nightly; the latter dose may be reserved for early-stage cancer patients who suffer from disturbed sleep patterns.

Melatonin should probably be taken 30 minutes to one hour before sleeping. Slow-release melatonin preparations may benefit those with various types of insomnia, as the oral bioavailability of melatonin is approximately 15%. Exposure to light at night, however, regardless of the duration or intensity of the light, can fully suppress or decrease melatonin levels.

Because most clinical studies have shown that patients with late-stage, advanced, or untreatable cancer, or those with cancer metastasis, benefit from supplementation with 20 mg of melatonin, such patients may wish to consider supplementing with between 6 and 50 mg of melatonin nightly, depending on plasma melatonin levels.

The phenomenon of light at night regulating melatonin levels may explain the spontaneous tumor regression reported to occur through meditation alone in cancer patients (when the eyes are closed and detect no light). The regular practice of meditation is associated with increased physiological levels of melatonin.

Thus, cancer patients with endogenously depressed melatonin levels may benefit from both meditation and substitutional melatonin therapy, to improve quality of life while potentially inhibiting tumor growth and spread.

The Magic of Myrrh

Myrrh’s scientific name is Commiphora Myrrha and is native to Egypt. While the resin was frequently used in incense and perfumes in ancient Egypt, and the oil obtained from it was used for healing wounds in ancient Greece.

It may be easy to understand gold being a precious gift, but in truth, frankincense and myrrh’s value far outweighs that of gold. These plants are healing on an emotional, physical and spiritual level and more than simply symbols of the Christmas season.

Myrrh Benefitsmyrrh

Anti-septic, anti-fungal and anti-inflammatory, anti-depressant, anti-microbial and anti-viral, astringent, expectorant, stimulant, carminative, stomachic, anti catarrhal, diaphoretic, vulnerary, anti-spasmodic, immune booster, improves circulation, body tonic.

Antioxidant benefits

A study published in the prestigious journal Food and Chemical Toxicology found that myrrh (Commiphora molmol) emulsion was able to protect against lead (PbAc)-induced hepatotoxicity.

The authors of the study concluded that myrrh emulsion is a “powerful antioxidant” that can “protect against PbAc-induced hepatic oxidative damage and immunotoxicity by reducing lipid peroxidation and enhancing the antioxidant and immune defense mechanisms.”

  • protects against coughs and colds (viral infections), provides relief from mucus and phlegm, eases congestion, breathing trouble, etc.
  • boosts and activates the immune system, prevents/aids microbial infections (cough, cold, fever, food poisoning, measles, chicken poxs etc.)
  • works as a fungicide

Possible anticancer properties

A group of Chinese researchers revealed that extracts and compounds from Commiphora myrrha resin may be effective against human gynecologic cancer cells.2 Their findings were published in the Journal of Medicinal Plants Research.

A 2011 study found that myrrh essential oil was effective in fighting cancer cells and did shrink tumor size. It’s been shown to be effective against skin cancer.

Mood Improvement

If you’re struggling with stress or anxiety or you just want to improve your overall mood and outlook on life, myrrh oil is one of the best essential oils to use.  Use in a diffuser for best results.

Skin Health

Myrrh oil is great for skin.  It’s effective against reducing wrinkles or age and sunspots as well.

  • heals wounds (essentially those of a ‘weeping’ nature), protects against infection and promotes healing
  • relieves skin diseases (eczema, ringworm, etc.)
  • soothes cracked and chapped skin
  • used in gum and mouth (ulcer) preparations

People are advised not to consume high amounts of myrrh as it can potentially cause severe heart irregularities, according to a study published in the journal Phytotherapy Research

Caution: Women who are pregnant should avoid taking myrrh by mouth as it may be a cause of miscarriage.

This Common Herb – a Profound Cancer Fighter?

In the Middle East we eat this herb on a near daily basis.tabbouleh

PARSLEY, is a common feature in our salads, various stuffings, breakfast condiments and egg dishes.  Tabbouleh, the traditional salad of Lebanon, is 60% Parsley. (Recipe Here)


This article was published by Ralph W. Moss, PhD, who has been writing about cancer — especially its less-conventional treatments — for over 35 years.

He has written/edited twelve books and three film documentaries on questions relating to cancer research and treatment. Moss is a graduate of New York University (BA, cum laude, Phi Beta Kappa, 1965) and Stanford University and a  former science writer and assistant director of public affairs at Memorial Sloan-Kettering Cancer Center in New York.

Parsley Component Found to Fight Cancer


In 1936, Albert Szent-Györgyi, MD, PhD, discovered a class of bioactive compounds that controlled hemorrhaging in certain medical conditions (Armentano 1936). These compounds are found in many plants, including his native Hungarian paprika and lemon juice. They were named bioflavonoids.tabbouli-making.jpg

In recent years, attention has focused on one particular flavone called. There are now over 3,000 PubMed-indexed journal articles discussing apigenin.

…in September 2015 Sanjeev Shukla, PhD, of Case Western Reserve University, Cleveland wrote such an article. He and the Ohio scientists team found that apigenin effectively inhibited a molecule called IKKα.

.. IKKα is a “key driver of the metastatic process” and therefore a “promising therapeutic target in anticancer drug research.”

…they have now identified an effective inhibitor of this undesirable enzyme—APIGENIN!

Apigenin, they wrote,

“exhibits anticancer efficacy in experimental tumor model.”

In mice, apigenin stops tumor growth, lowers the proliferation rate of malignant cells and enhances apoptosis (the predominant form of programmed cell death). They identified some other anticancer effects:

  • Causes cell cycle arrest in prostate cancer cells
  • Suppresses migration in cancer cells
  • Suppresses tumor growth in athymic nude mice

Apigenin and prostate cancer

“Accumulated evidence leads us to hypothesize that there is some distinct mechanism by which apigenin suppresses prostate cancer growth, and we believe this warrants further investigation.”

 A small clinical trial was performed in Groß-Gerau, Germany, and published by Prof. Harald Hoensch. His group gave a food supplement of 10 milligrams (mg) of apigenin as well as 10 mg of EGCg (a main ingredient in green tea) to patients who had either colorectal cancer or premalignant polyps of the colon. The results were dramatic. In the control group, 47 percent (7 out of 15) had recurrences. But in the treated group, only 7 percent (1 out of 14) had a recurrence.

The Most Abundant Sources

  • Dried Parsley leaves
  • Grapefruit

According to one nutritional Web site (merschat.com), dried parsley has an incredible 13,000 mg per 100 grams. In other words, it is 13 percent apigenin by weight!

Fresh parsley has a considerable 225 to 300 mg per 100 grams.

Other good sources:

  • peppermint
  • thyme
  • raw celery
  • rutabagas
  • also in chamomile flower tea

Put another way, one cup of chopped raw parsley has over 180 mg of apigenin. To get a 10 mg dose, as in the clinical trial, you would only need to take one tablespoon of raw chopped parsley per day. Alternately, you could sprinkle a small amount of dried parsley into your food.


The toxicity of apigenin consists of an occasional allergic reaction, or possibly an undesirable interactions with other drugs. There is, however, one laboratory study that seemed to show that although apigenin was effective at killing leukemia cells, it simultaneously interfered with one standard drug used in the chemotherapy of that same disease (Ruella-de-Sousa 2010). It thus might be wise to NOT take high doses of this chemical if you are currently undergoing chemotherapy for cancer.

At the very least you should discuss this with your oncologist. Most reasonable doctors would not object to you adding a tablespoon of parsley to your daily regimen. It could do a world of good.

Kombucha: A Healthy Fizzy Drink?

There are numerous brands of Kombucha on the market. Some are National Brands, but many are brands brewed locally in smaller quantities.

The prevalance of a large variety of this drink is proof that it has a large and growing consumer base. There are tutorials galore on how to brew your own Kombucha, and many people have joined that bandwagon.

I wanted to share this article about the benefits of Kombucha, and why it should replace any other fizzy drink in your refrigerator.
Kombucha The Healthy Fizzy Drink – CureJoy Editorial

Kombucha The Healthy Fizzy Drink



The Kombucha culture is a mix of a variety of yeasts (similar to those used in beer) and bacteria (similar to those used in yogurt) and a gelatinous cake called the symbiot. This culture acts like a veritable biochemical factory, transforming simple sugars into a multitude of highly beneficial substances.

Kombucha contains several types of enzymes and good bacteria:

  • organic acids
  • vitamins C, B1, B2, B3, B6, B12
  • amino acids
  • antioxidants and polyphenols and typically less than .5 % alcohol.

It is not unusual to come across sedimentation or a floating gelatinous substance. The presence of these substances is actually a good sign that the drink is raw and ready to drink.

In the newest research published in the Journal of Medicinal Food 2014, researchers from the University of Latvia say the following about the health benefits of kombucha:

“It is shown that [kombucha] can efficiently act in health preservation and recovery due to four main properties: detoxification, anti-oxidation, energizing potencies, and promotion of boosting immunity.”

The Origins of Kombucha

The origins of Kombucha are speculative at best. It is thought to have originated in the Far East, probably China, and has been consumed there for at least 2000 years.

In ancient Japanese texts Kombucha is mentioned the first time in 414 AD when emperor Inkyo was troubled with internal digestive problems and summoned his doctor, Dr Kombu, who introduced it to the imperial court and according to old scrolls has given the beverage its name.kombuc

Health Benefits

Many health claims about kombucha are not yet proven due to the lack of research studies. But, it has certainly been shown to have similar antibiotic, antiviral and anti-fungal properties in lab tests.

There is also a lot of experiential evidence from people who have been using kombucha over many years.

Many of the benefits reported include improvements in energy levels, metabolic disorders, allergies, cancer, digestive problems, candidiasis, hypertension, HIV, chronic fatigue and arthritis. It’s also used externally for skin problems and as a hair wash among other things.

.Calming effect: Kombucha tea contains certain acids that can calm your body and mind. Regular consumption of the tea can help you overcome stress, sleep disorders, depression, anxiety and other mental and emotional problems.

.Detoxifying: One of kombucha’s greatest health benefits is its ability to detox the body. Detoxification helps in cleansing the liver and aides in cancer prevention. Kombucha is very high in Glucaric acid, and recent studies have shown that glucaric acid helps prevent cancer.

.Cancer prevention: Kombucha has also been proven beneficial for preventing cancer. A study published in Cancer Letters found that consuming glucaric acid found in kombucha reduced the risk of cancer in humans.

.Weight loss: Data from a study in 2005 showed evidence that kombucha can improve metabolism and limit fat accumulation. Although more studies and research needs to be conducted before the results can be confirmed, other weight loss studies have adequately proven the acetic acid and polyphenols can lead to weight loss.

.Prevents arthritis: Kombucha contains glucosamines, a strong preventive treatment for all forms of arthritis. The Hyaluronic acid enables connective tissue to bind moisture thousands of times its weight and maintains tissue structure, moisture, lubrication and flexibility and lessens free radical damage, while associated collagen retards and reduces wrinkles.

.Aids digestion and maintains good gut health: Because it’s naturally fermented with a living colony of bacteria and yeast, Kombucha is a probiotic beverage. This has a myriad of benefits such as improved digestion, fighting candida (harmful yeast) overgrowth, mental clarity, and mood stability.

.Instant energy: Kombucha’s ability to invigorate people has been credited to the formation of iron that is released from the black tea during the fermentation process. It also contains some caffeine and b-vitamins, which can energize the body.

.Boosts immunity: Kombucha is rich in anti-oxidants which works wonders for boosting your immunity and energy levels.


The downside of this wonderful beverage is that kombucha’s probiotics do not survive the pasteurization process, and drinking it unpasteurized, if it was not produced in sanitary conditions, may pose a food safety threat, especially for those who are pregnant or have compromised immune systems.

Some of the reported side effects of excessive and/or contaminated kombucha consumption include stomach upset, acidosis, allergic reactions to the molds that can develop during fermentation, and toxicity from heavy metals from home-brewing in ceramic pots. The best way to consume the drink would be to brew it at home yourself.


Published by Ralph W. Moss, Ph.D., Cancer Advisor – Sept. 30, 2015
Graviola (Annona muricata) is a well-known folk remedy for cancer, with a devoted following in some countries.

It is used as a pesticide, antimalarial, antiparasitic and antimicrobial and now as an anticancer agent (Fang 1993). But these compounds also have some general cytotoxicity, which is related to their ability to interfere with the energy use by cells (Ahammadsahib 1993).

This is what may make this herb toxic to normal cells under some conditions and has brought it to the attention of various writers, not all of whom are sympathetic to its use.

Twenty years ago, Morré and his Purdue colleague, Jerry L. McLaughlin, PhD, carried out an experiment with one particular acetogenin, bullatacin, a fatty acid compound found in some Annonaceae fruit. They showed that it almost completely inhibited ENOX2 activity in HeLa cancer cells (Morré 1995).graviola no

Scientists in Atlanta, Georgia, recently showed that whole-plant extracts of graviola leaf are indeed toxic to cancer cells. However, they caution that this extract…

“despite its superior in vitro and in vivo efficacy, resulted in death of the mice due to toxicity” (Yang 2015).

This raises the question of whether graviola is too toxic to use, and, if it is used, how great is the risk to cancer patients? A particular concern is the presence of a neurotoxin, annonacin, in the leaves.

Alexander Schauss, PhD, a well-respected scholar in the field of natural products, has spoken out forcefully against the general use of graviola in food supplements. He says that there is an association between graviola consumption and “atypical” Parkinson’s disease. He did research on this topic a dozen years ago in Guam, where the consumption of graviola is common. A 2006 report from Guadaloupe similarly made a connection between graviola and Parkinsonism.

For that reason, I would say that cancer patients should stay away from graviola, until further research shows that it is both effective at inhibiting ENOX2 in humans and that there is a safe level of consumption that will not cause or contribute to Parkinson’s disease.

Pawpaw Tree

Another question is whether a related North American plant, pawpaw (Asimina triloba) might be a safe substitute for graviola. This tree produces a surprisingly delicious tropical-tasting fruit, even in the Eastern parts of the United States.

The topic of pawpaw and cancer deserves an article of its own. But the aforementioned Dr. Jerry McLaughlin has written that pawpaw contains “promising new antitumor…agents that are found only in the plant family Annonaceae” (Alali 1998). So there is promise in pawpaw.


Ahammadsahib KI, Hollingworth RM, McGovren JP, Hui YH, McLaughlin JL. Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin. Life Sci. 1993;53(14):1113-1120.

Alali FQ, Liu XX, McLaughlin JL. Annonaceous acetogenins: recent progress. J Nat Prod. 1999;62(3):504-540. doi:10.1021/np980406d.

Lannuzel A, Höglinger GU, Champy P, Michel PP, Hirsch EC, Ruberg M. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae? J Neural Transm Suppl. 2006;(70):153-157.

Morré DJ and Morré D. ECTO-NOX PROTEINS: GROWTH, CANCER AND AGING. New York: Springer, 2013. (List price of $267 but available from the Harvey H. and Donna M. Morré Foundation for Cancer Research, 1112 Cherry Lane, West Lafayette, IN 47906 by enclosing a check for a donation of $100 made out to the Foundation and also by providing a mailing address.)

Yang C, Gundala SR, Mukkavilli R, Vangala S, Reid MD, Aneja R. Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer. Carcinogenesis. 2015;36(6):656-665. doi:10.1093/carcin/bgv046.


D. James Morré, PhD
Dorothy Morré, Ph

Green tea is not the only thing that can inhibit ENOX2. There are several well-known anticancer agents that do so, including two jack-of-all-trade drugs, cisplatin and doxorubicin (better known by its trade name, Adriamycin®). Almost as powerful, and far less toxic, is a specific combination of concentrated green tea and pure chili pepper, which is sold as “Capsol-T.”

It combines these two ingredients in a particular ratio, which is determined experimentally for each product lot. This has the effect of blocking the dangerous ENOX2, which functions on the surface of cancer cells.

 “A major factor in the effectiveness of Capsol-T is the necessity to take the product every four hours even during the night. The effect of Capsol-T on ENOX2 is one of reversible inhibition….The effect of both green tea and Capsol-T is transient and goes away in a matter of a few hours. If cancer cells can be prevented from growing for more than three or four days they are likely to undergo programmed cell death.”

 There are currently ~6,000 scientific publications indexed in PubMed on the topic of green tea. Over ~2,000 of these contain references to the main medicinal substance found in tea, the polyphenol (or catechin) dubbed epigallocatechin gallate or EG

Cg. There are 1,300 articles referencing both EGCg and cancer.

 Large Amount of Research

Complementary and alternative medicine (CAM) subjects are usually deficient in solid research and, often, scientific research lags behind popular interest. But you can see that green tea is among the best researched subjects in the nutritional universe.

Unfortunately, the clinical investigation of green tea in human cancer patients has lagged behind the easier-to-perform laboratory studies. However, in the April 2015 issue of the journal Prostate,there was a very interesting article on the effects of brewed green tea compared to brewed black tea (and plain water) on various blood markers associated with prostate cancer development and progression.

Dr. Suzanne M. Henning and colleagues at the David Geffen School of Medicine, University of California, Los Angeles, CA (UCLA) conducted the study. In this phase II trial, 113 men who had been diagnosed with prostate cancer were randomized to consume six cups daily of brewed green tea, brewed black tea or water prior to undergoing a radical prostatectomy (RP) operation. The authors looked at a variety of markers of progression. Patients who consumed green tea (but not either black tea or water) had a significant decrease in the amount of nuclear factor kappa B [NFκB]. NFκB is a very important marker that is often associated with more aggressive cancers.

In fact, tea polyphenols (including EGCg) were detected in the prostate tissue of 32 of the 34 men who received green tea, but not in the two other groups. Evidence of a systemic antioxidant effect was  observed only with green tea consumption. Also, only green tea led to a statistically significant decrease in serum prostate-specific antigen (PSA) levels.

The authors concluded “future longer-term studies are warranted to further examine the role of GT [green tea, ed.] for prostate cancer prevention and treatment, and possibly for other prostate conditions such as prostatitis.”

In September, this conclusion was seconded by a well known urologist at New York University’s Langone Medical Center, New York, Samir S. Taneja, MD. Writing in the Journal of Urology(official journal of the American Urological Association), Taneja wrote:

 “The authors of this [UCLA, ed.] study provide a well executed trial with defined, measurable end points. While the study does not tell us if green tea will prevent prostate cancer or slow its growth, it offers insight into potential mechanisms and validates a biological effect of the agents, such that future clinical trials of efficacy appear warranted” (Taneja 2015).

Such a trial will probably be less significant if the green tea in question is given solely as a brewed drink than in the form proposed by the Morrés, namely as Capsol-T. The reason for this has to do with the presence of ENOX2 at the surface of most cancer cells (including prostate cancer cells) and the ability of various substances, including green tea catechins, to inhibit in turn the functions of ENOX2.

 It is important to note that Capsol-T must be taken according to a rigorous schedule.

Dr. Morré recently told me:

“A major factor in the effectiveness of Capsol-T is the necessity to take the product every four hours even during the night. The effect of Capsol-T on ENOX2 is one of reversible inhibition….The effect of both green tea and Capsol-T is transient and goes away in a matter of a few hours. If cancer cells can be prevented from growing for more than three or four days they are likely to undergo programmed cell death.

However, if the Capsol-T or green tea levels are intermittent, the cancer cells will resume growth when the levels reach a low blood level and the clock starts over again and will never be killed and through a ‘survival of the fittest’ selection process may even become resistant. This is why, to be effective, Capsol-T must be taken every 4 hours, even during the night” (personal communication, September 21, 2015).

For a better understanding, interested readers can and should read the Morrés’ articles (e.g., Hanau 2014) and, especially, their groundbreaking book, ECTO-NOX Proteins: Growth, Cancer, and Aging (Springer 2013).


Hanau C, Morré DJ, Morré DM. Cancer prevention trial of a synergistic mixture of green tea concentrate plus Capsicum (CAPSOL-T) in a random population of subjects ages 40-84. Clin Proteomics. 2014;11(1):2. doi:10.1186/1559-0275-11-2.

Henning SM, Wang P, Said JW, et al. Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy. Prostate. 2015;75(5):550-559. doi:10.1002/pros.22943.

Mangal M, Khan MI, Agarwal SM. Acetogenins as potential anticancer agents. Anticancer Agents Med Chem. June 2015.

Morré DJ, de Cabo R, Farley C, Oberlies NH, McLaughlin JL. Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes. Life Sci. 1995;56(5):343-348.

Taneja SS. Re: Randomized Clinical Trial of Brewed Green and Black Tea in Men with Prostate Cancer Prior to Prostatectomy. J Urol. 2015;194(3):704-705. doi:10.1016/j.juro.2015.06.050.

Yang C, Gundala SR, Mukkavilli R, Vangala S, Reid MD, Aneja R. Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer. Carcinogenesis. 2015;36(6):656-665. doi:10.1093/carcin/bgv046.